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In this remarkable NOVA, pioneering brain detective V.S. Ramachandran, hailed as "the Sherlock Holmes of neuroscience," tackles four mysterious cases and delivers mind-boggling conclusions. Investigate his breakthrough research in phantom limb syndrome, and how he discovered how the brain undergoes a massive "re-wiring" when a person loses a limb. And, discover how findings learned from brain injuries help us learn about the normal brain.